St. Jude Children's Research Hospital
Sr. Staff or Principal Software Engineer, Rust Genomics Infrastructure | Memphis, TN
hn · Sr. Staff or Principal Software Engineer, Rust Genomics Infrastructure · $125,840 - $238,160
Jose has exceptional Rust exposure and deep experience building production infrastructure at scale across multiple domains (voice platforms, data warehousing, emergency response systems), plus a strong CS foundation and willingness to learn new domains. However, he lacks demonstrated bioinformatics/genomics domain knowledge and his recent experience has heavily favored Python/TypeScript over Rust, with no evidence of leading large-scale Rust projects or mentoring senior engineers in Rust-heavy codebases—key requirements for a Sr. Staff/Principal role.
Hook: Your background scaling real-time infrastructure and building 0→1 products across multiple domains shows the systems thinking St. Jude needs, and your Rust skills position you well to lead the genomics infrastructure rebuild.
Missing: Bioinformatics domain expertise, Large-scale Rust project leadership, Genomics or life sciences software experience, Senior team mentorship in Rust ecosystems
Posting
St. Jude Children's Research Hospital | Sr. Staff or Principal Software Engineer, Rust Genomics Infrastructure | Memphis, TN | ONSITE (2x/week onsite) or REMOTE | $125,840 - $238,160 | https://www.stjude.org/ St. Jude Children's Research Hospital is hiring Rust software engineers to rebuild the genomics ecosystem in Rust. We work at the intersection of computer science and genomics, and we're trying to build a better foundation upon which genomics can be done using Rust. The primary project we’re working on is a bioinformatics workflow execution engine for local, HPC, and Cloud called Sprocket (https://github.com/stjude-rust-labs/sprocket). You can also check out the other projects we have going on at https://github.com/stjude-rust-labs. NOTE that prior experience in bioinformatics or biology is NOT required for any of the positions below. You must be interested in learning though! If you'd like to get a sense of what you'd be learning, check out the guide we wrote to teach software engineers about genomics here: https://learngenomics.dev. * Sr. Staff or Principal Software Engineer: https://talent.stjude.org/careers/JobDetail/Senior-Staff-Principal-Software-Engineer-Rust-Genomics-Infrastructure-JR6999/4886 With any questions, email me at clay.mcleod@stjude.org. Please do not email me your application directly—be sure to submit it through the job portal.